Insulin in bodybuilding

Insulin also promotes the release of glucose into cells via insulin receptors. Very high insulin concentrations lead to protein synthesis in highly stimulated muscle. It does this primarily by enhancing the initiation of the peptide chain.

These results make it more appealing to bodybuilders and athletes. This is because these factors combine to make ingested protein more efficient, by promoting the transport of amino acids into muscle cells.

We can clearly say that insulin is undoubtedly the essential anabolic agent for muscle tissue. It also increases bone density. Another mechanism that enhances the anabolic effect of insulin is that insulin increases your IGF (Insulin-like Growth Factor) in your body. No need to remind you that IGF-1 is a highly anabolic hormone.

Another unexpected aspect of insulin is its ability to increase the levels of LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone). This means that insulin stimulates gonadotropin secretion, exerting an anabolic effect by increasing the capacity of your LAPHT (hypothalamic-pituitary-testicular axis), which in turn leads to increased testosterone production.

Insulin also increases the binding capacity of anabolic steroids to androgen receptors, which strongly suggests the possibility of a synergistic effect of insulin when combined with steroids. Most bodybuilders confirm that insulin has a certain anabolic synergy when combined with growth hormone.

 

The relationship between insulin, IGF and HGH is very synergistic and all are interdependent in their actions. Use all three together, plus anabolic steroids and a fat burner will give you the strongest and most powerful muscle possible.

Of course, when something seems too good to be true, there's always a "but"!!!!

Unfortunately, the bad news is that insulin can easily stimulate the storage of fat mass.

As a general rule, most bodybuilders take insulin along with a fat burner or thyroid hormones such as... t3-Cytomel, as well as anabolic steroids and sometimes even HGH and IGF, for the reasons explained previously. All of this further reduces the likelihood of fat being stored and significantly increases the amount of muscle that will be gained.

Individual insulin requirements are generally between 0.3 and 1.0 IU/kg/day. Ensure your insulin dose is limited to between 15 and 45 IU. However, this will largely depend on your daily carbohydrate intake. During a diet or cutting phase, the dosage should be reduced further. Most bodybuilders use up to three insulin injections daily.

• The first dose is administered immediately upon waking.,
• The second dose occurs sometime around noon.
• The third and final consumption is done right after you have finished your workout for the day.

 

Actrapid HM Penfill Novo Nordisk Rapid Insulin

Normally, insulin is produced by the pancreas and then released into the bloodstream. It acts within seconds, and its production, called secretion, varies constantly according to the body's needs. Rapid-acting or regular insulin, such as Actrapid HM Penfill, is laboratory-made insulin that is identical to the insulin naturally produced by the human body.

However, while we know how to perfectly manufacture insulin in the laboratory, we don't (yet) know how to release it into the bloodstream while constantly varying its level according to needs. This is the major problem with its route of administration: determining how it will reach the bloodstream.

Because it is destroyed in the stomach, insulin cannot be taken in tablet or oral ampoule form. The only method used is the well-known insulin injection, administered under the skin (subcutaneously). But once insulin is under the skin, it still needs to travel to the blood vessels, and this takes time. This is why rapid-acting insulin ultimately acts rather slowly. Its effects begin approximately 15 to 30 minutes after the injection and last about 6 hours.

Because rapid insulin acts too slowly compared to the rapid influx of carbohydrates from a meal, efforts have been made to develop faster insulins.

Researchers have succeeded in slightly changing the structure of insulin and have resulted in a modified insulin that acts faster, stronger and for a shorter time: these are the "rapid insulin analogs" like HUMALOG insulin.

After subcutaneous administration, Humalog acts rapidly and has a shorter duration of action (2 to 5 hours) than rapid-acting insulin. This rapid action allows for an injection of Humalog (or, in the case of continuous subcutaneous administration, a Humalog bolus) to be administered very shortly before or after a meal. The time course of action of any insulin can vary considerably between individuals or at different times in the same individual. The onset of action, which is faster than that of rapid-acting human insulin, is maintained regardless of the injection site. As with all insulin preparations, the duration of action of Humalog depends on the dose, the injection site, blood flow, temperature, and physical activity.

 

Insulatard Penfill Novo Nordisk slow insulin

Regular insulin has a duration of action of approximately 6 hours. To achieve effects lasting 12 to 24 hours, researchers developed longer-acting insulins. They had the idea of adding crystals of a product called Protamine to the insulin: once injected subcutaneously, the insulin detaches slowly and therefore acts for a longer period. This is how NPH insulin, such as Insulatard, came about.

It is an insulin identical to human insulin, produced using biotechnology. It has a long duration of action: its effect appears approximately 1 hour 30 minutes after injection and wears off after 24 hours. Insulatard is often administered in combination with rapid-acting insulins.

This insulin should only be injected subcutaneously, trying to vary the injection sites to avoid the appearance of lipodystrophies (nodules and thickening of the skin).

Before injection, gently swirl the suspension to homogenize it.

For greater comfort, insulin can be taken out of the refrigerator one hour before injection or warmed in the hands for a few minutes, then injected at room temperature.

In the case of sporting activity, it is preferable to inject insulin away from the muscles worked during your training to avoid too rapid absorption.

 

 

Mixtard 30 HM Penfill Nordisk Mix slow and rapid insulin

To avoid multiplying insulin injections, researchers had the idea of mixing long-acting insulin (NPH) and fast-acting insulin (Actrapid).

This insulin mixture is called Mixtard (Novo Nordisk)

Mixtard is a mixture of rapid-acting and long-acting insulin. This means it starts lowering your blood sugar about half an hour after administration, and the effect lasts for about 24 hours.

 

Insulin administration

Subcutaneous administration

Insulin is usually administered subcutaneously through the abdominal wall. Injections can also be given in the thigh, gluteal region, or deltoid region.

A subcutaneous injection into the abdominal wall ensures faster absorption than in other injection sites.

Injecting into a skin fold reduces the risk of accidental intramuscular injection.

After the injection, the needle must remain under the skin for at least 6 seconds to ensure that the entire dose is injected.

The injection site is determined by the type of insulin to be injected. …

 

Special storage precautions for insulin

Keep between +2°C and +8°C (in the refrigerator), away from the freezer compartment.

Do not freeze.

Keep the container in the outer packaging to protect from light.

During use: do not refrigerate.

Do not store above +30°C.

Store away from excessive heat and light

 

Insulin shelf life

Store unused insulin cartridges in the refrigerator until needed. They can be used up to the expiry date printed on the label. Avoid freezing.

You can keep opened insulin at room temperature, but you will need to discard it after 28 days.